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Updated: Dec 31, 2025

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
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Formation of Synthetically Versatile 2-Aminobenzophenones from Readily Accessed Acyl Hydrazides
Nehaal Ahmed1, André Shamsabadi1, Vijay Chudasama1
1Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K.
Abstract:
Herein, we report the transformation of readily accessed acyl hydrazides into protected 2-aminobenzophenones via a two-step process involving an aryne-based molecular rearrangement followed by a one-pot addition-elimination procedure. The assembly of the scaffold is tolerant of a wide variety of functional groups, and the carbamate group on the product can be facilely removed to afford highly valuable 2-aminobenzophenones. Application of the protocol was demonstrated in the synthesis of neurological medicine phenazepam.
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