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Updated: Dec 31, 2025

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
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A Nanovessel-Catalyzed Three-Component Aza-Darzens Reaction

Stephen M Bierschenk1, Robert G Bergman1, Kenneth N Raymond1

  • 1Chemical Sciences Division, Lawrence Berkeley National Laboratory and Department of Chemistry , University of California , Berkeley , California 94720 , United States.

Journal of the American Chemical Society
|January 8, 2020
PubMed
Summary

Supramolecular host catalysis enables a three-component Aza-Darzens reaction, yielding N-phenylaziridines. This supramolecular approach achieves stereoselectivity opposite to bulk solution, advancing complex organic synthesis.

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