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Brain MRI with Quantitative Susceptibility Mapping: Relationship to CT Attenuation Values.

Sonoko Oshima1, Yasutaka Fushimi1, Tomohisa Okada1

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Quantitative susceptibility mapping (QSM) and CT attenuation values correlate with metal concentration in phantoms. In humans, CT values correlate with magnetic susceptibility in brain structures and lesions, aiding in differentiating calcification and iron deposits.

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Area of Science:

  • Radiology
  • Medical Imaging
  • Neuroimaging

Background:

  • Quantitative susceptibility mapping (QSM) is crucial for distinguishing calcification from iron deposits.
  • Limited research exists on the correlation between CT attenuation values and magnetic susceptibility in these materials.
  • Understanding these relationships is vital for accurate tissue characterization in medical imaging.

Purpose of the Study:

  • To investigate the relationship between metal concentration, CT attenuation values, and magnetic susceptibility in paramagnetic and diamagnetic phantoms.
  • To assess the correlation between CT attenuation values and magnetic susceptibility in human brain structures and lesions with paramagnetic or diamagnetic properties.

Main Methods:

  • Retrospective analysis of CT and MRI with QSM data from gadolinium and calcium phantoms, patients, and healthy volunteers.
  • Phantom studies evaluated correlations among metal concentration, CT attenuation, and QSM values.
  • Human studies used Pearson and Spearman correlations to assess CT attenuation values and susceptibility in specific brain regions and lesions.

Main Results:

  • Strong linear correlations were found between gadolinium concentration and CT/QSM values (R²=0.95, R²=0.99) and calcium concentration and CT/QSM values (R²=0.89, R²=0.98).
  • Positive correlations between CT attenuation values and susceptibility were observed in the globus pallidus (R²=0.52) and hemorrhagic lesions (R²=0.38).
  • Negative correlations were found in the choroid plexus (R²=0.53) and calcified lesions (R²=0.38).

Conclusions:

  • CT attenuation values demonstrate a positive correlation with magnetic susceptibility in the globus pallidus and hemorrhagic lesions.
  • A negative correlation was observed between CT attenuation values and susceptibility in the choroid plexus and calcified lesions.
  • These findings highlight the utility of correlating CT attenuation values with QSM for characterizing brain tissues and lesions.