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Defining Symptom Concepts in Chronic Subjective Tinnitus: Web-Based Discussion Forum Study.

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This study refined definitions for core tinnitus outcome domains, establishing measurable constructs for clinical trials. Experts reached consensus on most definitions, improving tinnitus research comparability.

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Area of Science:

  • Medical research methodology
  • Audiology and otolaryngology
  • Health outcomes research

Background:

  • Clinical trials require standardized outcome domains for tinnitus research.
  • A consensus-based minimum standard recommends core outcome domains for comparability and meta-analysis.
  • Operationalizing abstract concepts into measurable constructs is crucial for instrument selection.

Purpose of the Study:

  • To refine and operationalize definitions for five core tinnitus outcome domains: intrusiveness, sense of control, acceptance, concentration, and ability to ignore.
  • To move from abstract concepts to measurable health-related constructs for tinnitus assessment.
  • To facilitate the identification of suitable measurement instruments for tinnitus clinical trials.

Main Methods:

  • Conducted five online focus group-style semistructured discussions with 148 tinnitus experts.
  • Participants included patients, healthcare professionals, researchers, industry representatives, and funders.
  • Discussions were web-based, open for two weeks, and concluded with a consensus vote.

Main Results:

  • Revised plain language definitions for all five outcome domains were generated.
  • Consensus (≥70%) was achieved for four domains; tinnitus intrusiveness definition required broader scope.
  • Thematic analysis provided insights into expert interpretations, operationalizing each domain as a measurable construct.

Conclusions:

  • Web-based discussions enhanced understanding of debated health concepts, aiding core outcome set development.
  • The operationalized definitions are sufficient for selecting appropriate measurement instruments.
  • Web-based peer discussion forums are effective for defining health concepts in research.