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Cytotoxic Activity of Cunila angustifolia Essential Oil
Matheus H O de Sousa1, Jessica M S Morgan1, Karina Cesca2
1Natural Products Research Group, Federal University of Rio Grande, St. Cel. Francisco Borges de Lima, n. 3005, Bom Princípio, Santo Antônio da Patrulha, 95500-000, RS, Brazil.
Abstract:
The Cunila angustifolia essential oil was obtained from fresh leaves by hydrodistillation and analyzed by GC-FID and GC-MS to determine its chemical composition. The essential oil presented pulegone (29.5 %) and isomenthol (27.0 %) as major components, and other compounds such as menthone (8.6 %), neomenthol (7.2 %), menthyl acetate (2.5 %) and caryophyllene oxide (2.0 %) were identified. The cytotoxic activity of the essential oil was evaluated by MTS assay, with the human cancer cell lines of the lung (A549), breast (MCF-7) and skin melanoma (SK-Mel-28). The assay showed the highest selectivity, to MCF-7 cell lines, with IC50 equal to 34.0 μg mL-1 , low selectivity for SK-Mel-28 cell lines, with IC50 equal to 279.9 μg mL-1 , and no mortality to A549 cell lines.
