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Martin Preisig1, Marie-Pierre F Strippoli1, Caroline L Vandeleur1

  • 1Département de Psychiatrie, Centre d'Epidémiologie Psychiatrique et de Psychopathologie, Centre hospitalier universitaire vaudois (CHUV) et Université de Lausanne, Lausanne.

Praxis
|January 9, 2020
PubMed
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PsyCoLaus found major depressive disorder affects 43.6% of Lausanne adults. Atypical depression subtypes significantly increase risks for cardiovascular diseases, including obesity and metabolic syndrome.

Area of Science:

  • Psychiatry
  • Cardiology
  • Epidemiology

Background:

  • Mental health disorders, particularly depression, are increasingly linked to cardiovascular diseases.
  • Understanding the specific subtypes of depression and their association with metabolic risk factors is crucial for targeted interventions.

Purpose of the Study:

  • To determine the prevalence and course of mental disorders in the general population.
  • To investigate the mechanisms linking mental disorders and cardiovascular diseases.
  • To identify specific depression subtypes associated with cardio-metabolic risk.

Main Methods:

  • Prospective cohort study (PsyCoLaus) in Lausanne.
  • Assessment of mental disorders, cognitive functioning, and cardiovascular risk factors.
  • Analysis of depression subtypes and their correlation with metabolic health.
Keywords:
EpidemiologieLängsschnittstudieProspective studycardio-metabolic risk factorscardiovascular diseasesepidemiologyfacteurs de risque cardio-métaboliqueskardiometabolische Risikofaktorenkardiovaskuläre Erkrankungenmaladies cardiovasculairesmental disorderspsychiatrische Störungentroubles mentauxÉtude prospectiveépidémiologie

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Main Results:

  • A high lifetime prevalence of 43.6% for major depressive disorder was observed in Lausanne.
  • The association between major depression and cardio-metabolic risk factors is primarily linked to the atypical subtype of depression.
  • Atypical depression is characterized by increased appetite, limb heaviness, hypersomnia, and preserved affective reactivity.

Conclusions:

  • Atypical depression significantly elevates the risk of developing overweight, diabetes, and metabolic syndrome.
  • Individuals with atypical depression require focused clinical attention regarding metabolic health.
  • Findings highlight the importance of recognizing and managing specific depression subtypes to mitigate cardiovascular disease risk.