Potential of phytochemicals as immune-regulatory compounds in atopic diseases: A review

Area of Science:

• Immunology
• Dermatology
• Pharmacology

Background:

• Atopic diseases, including atopic dermatitis, asthma, and allergic rhinitis, are increasingly prevalent globally.
• Redox imbalance is a critical factor in the inflammatory processes underlying these allergic conditions.
• Complementary and alternative medicine, particularly natural compounds, are being explored for their antioxidant and anti-inflammatory properties.

Purpose of the Study:

• To investigate the impact of phytochemicals on redox-linked cellular and signaling pathways involved in atopic disease manifestation.
• To identify research gaps and propose future strategies for enhancing the clinical efficacy of phytochemicals in treating atopic diseases.

Main Methods:

• Review of existing literature on phytochemicals, redox balance, and atopic disease pathogenesis.
• Analysis of cellular signaling pathways affected by phytochemicals in experimental models.
• Exploration of bioavailability challenges associated with natural compounds.

Main Results:

• Phytochemicals demonstrate antioxidant and anti-inflammatory potential in pre-clinical studies, suppressing allergic responses.
• Evidence suggests phytochemicals influence critical redox-linked cellular and signaling pathways implicated in atopic diseases.
• Clinical success of phytochemicals has been limited, potentially due to poor absorption and bioavailability.

Conclusions:

• Phytochemicals hold therapeutic potential for atopic diseases by modulating redox imbalance.
• Improving the bioavailability of phytochemicals is crucial for translating pre-clinical findings into clinical success.
• Further research is warranted to develop strategies for optimizing phytochemical efficacy in managing allergic conditions.