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Shockwave Therapy Efficiently Cures Multispecies Chronic Periodontitis in a Humanized Rat Model
Akshay Datey1,2,3, C S Adeeb Thaha4, Sudhir R Patil4
1Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Frontiers in Bioengineering and Biotechnology
|January 9, 2020
Summary
Shockwaves show promise in combating dental biofilms, offering a novel approach to managing periodontal disease. Combined with antimicrobials, shockwave therapy significantly clears multispecies oral biofilms, potentially overcoming antibiotic resistance.
Area of Science:
- Oral microbiology
- Biomedical engineering
- Periodontology
Background:
- Biofilms are primary etiological factors in prevalent oral diseases like periodontitis and dental caries.
- Current antimicrobial treatments face challenges due to biofilm-induced antibiotic tolerance and resistance.
- Novel strategies are needed for effective biofilm control in periodontal therapy.
Purpose of the Study:
- To investigate the efficacy of shockwaves in managing multispecies oral biofilms derived from periodontitis patients.
- To evaluate shockwave therapy alone and in combination with antimicrobials.
- To explore shockwaves as a novel therapeutic approach for biofilm-associated periodontal disease.
Main Methods:
- Multispecies biofilms were developed from subgingival plaque of 25 chronic periodontitis patients.
- Biofilm analysis included scanning electron microscopy, atomic force microscopy, and biomass quantification.
- A humanized rat model of periodontitis was established and treated with shockwaves and/or antimicrobials.
Main Results:
- Shockwave treatment significantly enhanced the clearance of multispecies oral biofilms when combined with antimicrobials.
- The study demonstrated the potential of shockwaves in disrupting oral biofilm development.
- A humanized rat model showed successful infection establishment and treatment response.
Conclusions:
- Shockwave therapy, particularly in combination with antimicrobials, is effective against multispecies oral biofilms.
- This approach offers a novel strategy for managing biofilm-associated periodontal disease.
- Further research, safety validation, and clinical trials are warranted to establish shockwaves as a clinical tool.
