Recent trends in catalytic sp3 C-H functionalization of heterocycles
Milanpreet Kaur1, Jeffrey F Van Humbeck1
1Department of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada T2N 1N4. jeffrey.vanhumbec1@ucalgary.ca.
Abstract:
Heterocycles are a ubiquitous substructure in organic small molecules designed for use in materials and medicines. Recent work in catalysis has focused on enabling access to new heterocycle structures by sp3 C-H functionalization on alkyl side-chain substituents-especially at the heterobenzylic position-with more than two hundred manuscripts published just within the last ten years. Rather than describing in detail each of these reports, in this mini-review we attempt to highlight gaps in existing techniques. A semi-quantitative overview of ongoing work strongly suggests that several specific heterocycle types and bond formations outside of C-C, C-N, and C-O have been almost completely overlooked.
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