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Updated: Dec 31, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
[Head and neck cancer in the elderly-current aspects]
B Höing1, S Lang2, M Stuschke3
1Klinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Deutschland. benedikt.hoeing@uk-essen.de.
Geriatric head and neck cancer patients require careful pretreatment risk stratification. This study provides a clinical algorithm to guide decisions on invasive treatments for elderly patients with head and neck tumors.
Area of Science:
- Otorhinolaryngology
- Geriatric Oncology
- Surgical Oncology
Background:
- Head and neck cancer treatment relies heavily on surgery and radiochemotherapy, often causing high morbidity.
- Elderly patients present unique challenges, questioning the rationality of aggressive treatments due to limited data and guidelines.
- The increasing proportion of geriatric patients with head and neck tumors necessitates tailored clinical approaches.
Purpose of the Study:
- To establish concrete clinical recommendations for geriatric patients with head and neck tumors.
- To base recommendations on a systematic literature search.
- To aid decision-making regarding invasive treatment for elderly head and neck cancer patients.
Main Methods:
- A systematic literature search using keywords was conducted.
- The current evidence level for geriatric head and neck cancer treatment was assessed.
- A clinical algorithm for risk stratification was developed.
Main Results:
- Pretreatment evaluation for geriatric patients must include age, psychosocial status, functional capacity, and medical comorbidities.
- An algorithm was created for individual pretreatment risk stratification based on comprehensive patient data.
- This approach facilitates personalized decisions for or against invasive treatment.
Conclusions:
- Pretreatment risk stratification is crucial for deciding on invasive treatment for geriatric head and neck cancer patients.
- Current evidence is limited, highlighting the need for further research.
- A clinical algorithm is provided to assist otorhinolaryngologists and head and neck surgeons.
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