Related Experiment Video
Updated: Dec 31, 2025

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
Published on: July 24, 2019
Metabolic regulation of neurodifferentiation in the adult brain
Camilla Maffezzini1,2,3, Javier Calvo-Garrido1,4, Anna Wredenberg5,6,7
1Max Planck Institute Biology of Ageing-Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden.
Abstract:
Understanding the mechanisms behind neurodifferentiation in adults will be an important milestone in our quest to identify treatment strategies for cognitive disorders observed during our natural ageing or disease. It is now clear that the maturation of neural stem cells to neurones, fully integrated into neuronal circuits requires a complete remodelling of cellular metabolism, including switching the cellular energy source. Mitochondria are central for this transition and are increasingly seen as the regulatory hub in defining neural stem cell fate and neurodevelopment. This review explores our current knowledge of metabolism during adult neurodifferentiation.
Related Concept Videos
Neurogenesis and Regeneration of Nervous Tissue
Neural Regulation
Neuroplasticity

