A French Value Set for the EQ-5D-5L

Area of Science:

• Health Economics
• Quality of Life Research
• Societal Valuation of Health

Background:

• The EQ-5D-5L (5-level EuroQol 5-dimensions) is a widely used instrument for measuring health-related quality of life.
• Developing country-specific value sets is crucial for accurate health economic evaluations.
• Existing French value sets may not fully capture current societal preferences or utilize the full descriptive capacity of the EQ-5D-5L.

Purpose of the Study:

• To develop a new, representative French societal value set for the EQ-5D-5L instrument.
• To provide a tool for academic, clinical, and regulatory use in France, including drug and medical device price setting.
• To establish a robust dataset for health economic analyses within the French context.

Main Methods:

• Utilized the standardized EuroQol valuation protocol with a representative sample of 1048 French residents.
• Employed composite time trade-off and discrete choice experiment methods for health state valuation.
• Developed a hybrid modeling approach, including an adjusted model to ensure sample representativeness, to generate values for all 3125 EQ-5D-5L health states.

Main Results:

• An adjusted hybrid model was selected for its representativeness of the French population.
• The resulting value set demonstrated logical consistency, with values ranging from -0.525 to 1.
• A shift towards higher values was observed compared to the 3-level (3L) EQ-5D value set, with notable changes in dimension rankings (e.g., pain and discomfort, mobility).

Conclusions:

• The study successfully generated a French EQ-5D-5L value set reflecting current societal preferences.
• This value set will enhance the quality of cost-effectiveness analyses in France.
• It serves as a valuable resource for academic, institutional, and industry-sponsored studies requiring disease-specific quality-of-life data.