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Updated: Dec 31, 2025
Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
Published on: July 21, 2023
Adenosine triphosphate responsive metal-organic frameworks equipped with a DNA structure lock for construction of a
Caijun Wu1, Shufan Wang1, Xiliang Luo2
1Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, P. R. China. yuanruo@swu.edu.cn xiayang2@swu.edu.cn.
Abstract:
A novel ratiometric surface-enhanced Raman scattering (SERS) biosensor was constructed based on stimuli-responsive DNA functionalized metal organic frameworks (MOFs) for detection of adenosine triphosphate (ATP). As a result, the detection range of ATP was 1 nM to 200 nM with a detection limit of 0.4 nM. The ratiometric SERS biosensor strategy offers a lower detection limit and exhibits a more enhanced performance than the typical SERS detection based on single signal response, which may have potential for detection of other biomolecules or metal ions.
