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Expression analysis of inflammatory response-associated genes in coronary artery disease

Nader Ebadi1, Soudeh Ghafouri-Fard1, Mohammad Taheri2

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Archives of Physiology and Biochemistry
|January 9, 2020
PubMed

Insights

Inflammation-associated genes, including Antisense noncoding RNA in the INK4 locus (ANRIL), NKILA, and IL-1B, are down-regulated in coronary artery disease (CAD) patients, indicating their role in CAD pathogenesis.

Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Immunology

Background:

  • Coronary artery disease (CAD) is a leading global cause of mortality.
  • Inflammatory processes are implicated in the development of CAD.

Purpose of the Study:

  • To compare the expression levels of three inflammation-associated genes: Antisense noncoding RNA in the INK4 locus (ANRIL), NKILA, and IL-1B.
  • To investigate the role of these genes in the pathogenesis of CAD.

Main Methods:

  • A case-control study design was employed.
  • Gene expression levels were compared between CAD patients and matched healthy controls.
  • Analysis was stratified by gender.

Main Results:

  • ANRIL, NKILA, and IL-1B were significantly down-regulated in CAD patients compared to controls.
  • ANRIL and NKILA down-regulation was observed in both male and female CAD patients.
  • IL-1B was significantly down-regulated only in female CAD patients.

Conclusions:

  • The study demonstrates dysregulation of inflammation-associated genes in the peripheral blood of CAD patients.
  • These findings support the involvement of inflammation in the pathogenesis of CAD.
Abstract

Keywords:
ANRILCoronary artery diseaseIL-1BNF-κB interacting long noncoding RNANKILAantisense noncoding RNA in the INK4 locuslncRNA

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