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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Direct cyclohexanone oxime synthesis via oxidation-oximization of cyclohexane with ammonium acetate
1National & Local United Engineering Laboratory for New Petrochemical Materials & Fine Utilization of Resources, Key Laboratory of Chemical Biology Traditional Chinese Medicine Research Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. China. zwenz79@163.com mlq1010@126.com.
Abstract:
An unexpected cascade reaction for oxidation-oximization of cyclohexane with ammonium acetate was developed for the first time to access cyclohexanone oxime with 50.7% selectivity (13.6% conversion). Tetrahedral Ti sites in Ni-containing hollow titanium silicalite can serve as bifunctional catalytic centers in the reaction. This methodology not only provides a direct approach to prepare cyclohexanone oxime, but also simplifies process chemistry. Various available nitrogen sources, such as ammonium salt and even ammonia can be used as starting materials.
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