Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

2.5K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
2.5K
Nomenclature of Alkynes02:39

Nomenclature of Alkynes

20.8K
Alkynes are unsaturated hydrocarbons characterized by the presence of carbon-carbon triple bonds and have a general formula CnH2n-2. The nomenclature of alkynes follows a set of rules similar to alkanes and alkenes; however, alkynes bear the suffix "-yne" instead of "-ane" or "-ene." There are two approaches to naming alkynes:
20.8K
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis01:07

Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis

4.3K
Acetoacetic ester synthesis is a method to obtain ketones from alkyl halides and β-keto esters. The reaction occurs in the presence of an alkoxide base that abstracts the acidic proton of the β-keto esters. The step results in an enolate ion which is doubly stabilized. The enolate then reacts with an alkyl halide via the SN2 process to produce an alkylated ester intermediate with a new C–C bond. The hydrolysis of the intermediate, followed by acidification, results in an...
4.3K
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

2.2K
Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
2.2K
Alkylation of β-Diester Enolates: Malonic Ester Synthesis01:14

Alkylation of β-Diester Enolates: Malonic Ester Synthesis

4.0K
Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
4.0K
Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones01:24

Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones

5.5K
Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

European Society of Contact Dermatitis Guideline for Diagnostic Patch Testing-Recommendations on Best Practice (Update 2026).

Contact dermatitis·2026
Same author

Delayed hypersensitivity reaction to cetirizine suggesting involvement of piperazine ring: a case report.

Allergologia et immunopathologia·2026
Same author

Prospective Multi-Centre Photopatch Test Study of Photoallergy to Sunscreens and NSAIDs in Europe.

The British journal of dermatology·2026
Same author

Occupational Allergy to Rat and Mouse in Research Laboratories.

Current allergy and asthma reports·2026
Same author

The Hidden Sensitising Impurities and Additives in Cosmetic Raw Materials: A Call for Greater Transparency.

Contact dermatitis·2025
Same author

Trends in Benzisothiazolinone Sensitization: A Retrospective Analysis From 2010 to 2022, in a Tertiary Belgian Hospital.

Contact dermatitis·2025
Same journal

The Toxin of the Year: Airborne PM<sub>2.5</sub>.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Eyelid Dermatitis: A 5-Year Retrospective Review from a Metropolitan Contact Dermatitis Clinic.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

<i>Letter:</i> Anogenital Dermatitis Rarely Occurs in Isolation: Disease Distribution and Delays in Patch Testing.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Practical Techniques: Photopatch Testing.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Assessment and Clinical Management of Patients With Atopic Dermatitis Undergoing Patch Testing: Recommendations From an International Electronic Delphi Consensus.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Digital Image Superimposition for Identifying Delayed Patch Test Reactions: A Clinical Pearl.

Dermatitis : contact, atopic, occupational, drug·2026
See all related articles

Related Experiment Video

Updated: Dec 31, 2025

Stereolithographic 3D Printing with Renewable Acrylates
08:28

Stereolithographic 3D Printing with Renewable Acrylates

Published on: September 12, 2018

9.9K

Isobornyl Acrylate.

Olivier Aerts1, Anne Herman, Martin Mowitz

  • 1From the *Department of Dermatology, University Hospital Antwerp (UZA) and University of Antwerp †Department of Dermatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium ‡Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden §Department of Dermatology, University Hospitals, KU Leuven, Belgium.

Dermatitis : Contact, Atopic, Occupational, Drug
|January 9, 2020
PubMed
Summary
This summary is machine-generated.

Isobornyl acrylate (IBOA) is a newly identified contact allergen in diabetes devices like glucose sensors. Further research is needed on its cross-reactivity and industry cooperation is crucial for patient safety.

More Related Videos

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
09:09

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Published on: February 27, 2016

10.5K
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
08:56

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

3.3K

Related Experiment Videos

Last Updated: Dec 31, 2025

Stereolithographic 3D Printing with Renewable Acrylates
08:28

Stereolithographic 3D Printing with Renewable Acrylates

Published on: September 12, 2018

9.9K
Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
09:09

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Published on: February 27, 2016

10.5K
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
08:56

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

3.3K

Area of Science:

  • Dermatology
  • Allergology
  • Medical Device Regulation

Background:

  • Isobornyl acrylate (IBOA) was previously considered a low-risk sensitizer.
  • IBOA is now identified as a significant contact allergen in medical devices for diabetes management.
  • Diabetes devices such as glucose sensors and insulin pumps are widely used globally.

Purpose of the Study:

  • To highlight isobornyl acrylate (IBOA) as a major contact allergen in diabetes devices.
  • To investigate the remaining questions regarding IBOA's sensitization profile, including cross-reactivity.
  • To emphasize the need for improved cooperation from the medical device industry in identifying allergens.

Main Methods:

  • Multidisciplinary collaboration among European dermatology departments.
  • Patch testing to evaluate contact sensitization.
  • Analysis of clinical case data linking IBOA to allergic contact dermatitis in diabetes device users.

Main Results:

  • Isobornyl acrylate (IBOA) is identified as a primary contact allergen in glucose sensors and insulin pumps.
  • Further investigation is required for IBOA's cross-reactivity with other acrylates and its association with sesquiterpene lactones.
  • Challenges in obtaining industry cooperation hindered the identification process.

Conclusions:

  • The discovery of IBOA underscores the need for enhanced medical device regulation and compulsory labeling.
  • Increased cooperation between industry, dermatologists, and policymakers is essential for patient safety.
  • The IBOA case serves as a precedent for addressing allergic contact dermatitis in medical device users.