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Statins reduce new-onset atrial fibrillation after acute myocardial infarction: A nationwide study

Chien-Hao Tseng1, Wen-Jung Chung1, Chen-Yu Li2,3

  • 1Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Branch, Kaohsiung.

Medicine
|January 9, 2020
PubMed

Insights

Statins may help reduce new cases of atrial fibrillation (AF) after acute myocardial infarction (AMI). This study found statin use was associated with a lower risk of new-onset AF in AMI patients.

Area of Science:

  • Cardiology
  • Pharmacology
  • Epidemiology

Background:

  • Atrial fibrillation (AF) is a significant complication following acute myocardial infarction (AMI).
  • The relationship between AF and lipid profiles is not well understood, and the role of statins in preventing new-onset AF post-AMI is debated.
  • Existing AF and new-onset AF after AMI are associated with worse cardiovascular outcomes compared to no AF.

Purpose of the Study:

  • To investigate the potential beneficial effect of statin therapy on the incidence of new-onset AF in patients with AMI.
  • To analyze cardiovascular outcomes in patients with existing AF, new-onset AF, and no AF after AMI.

Main Methods:

  • Retrospective analysis of 32,886 AMI patients from the Taiwan National Health Insurance Research Database (2008-2011).
  • Complete 1-year follow-up data was available for 27,553 patients.
  • Cardiovascular outcomes including heart failure, stroke, all-cause death, major adverse cardiac and cerebrovascular event (MACCE), and myocardial re-infarction (re-MI) were compared based on AF status and statin use.

Main Results:

  • Patients with AF (existing or new-onset) had significantly higher rates of heart failure, stroke, all-cause death, and MACCE post-AMI compared to the non-AF group (P < .05).
  • Myocardial re-infarction rates did not differ significantly among the AF groups (P = .95).
  • Statin use was associated with a trend towards a lower risk of new-onset AF after AMI (HR: 0.935; 95% CI: 0.877-0.998; P = .0427).

Conclusions:

  • Both existing and new-onset AF following AMI are linked to poorer cardiovascular outcomes.
  • Statin therapy shows a potential protective effect, tending to reduce the incidence of new-onset AF after acute myocardial infarction.

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