Noradrenaline excites neurons in the guinea pig cerebellar vermis in vitro

Noradrenaline (NA) was applied to the solution bathing the cavy cerebellar vermis in vitro and the responses of 98 neurons were recorded extracellularly. Two thirds (23/35) of the responses were excitations and the remaining third were inhibitions. The lowest concentration of NA with which responses could be obtained was 10(-11) M NA. Responses were generally transient and occurred with a mean latency of 61 +/- 8 sec. The excitation was generally direct as most responses (9/11) survived synaptic blockade. The excitations were thought to be mediated by alpha 1 receptors because they could be mimicked by phenylephrine and antagonised by prazozin.