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Protein Glycosylation

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...

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Updated: Dec 31, 2025

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

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Novel methods in glycomics: a 2019 update.

Wei-Qian Cao^1,2, Ming-Qi Liu¹, Si-Yuan Kong¹

¹Shanghai Fifth People's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Expert Review of Proteomics

|January 10, 2020

Summary

Glycomics aims to define biological glycans but faces complexity challenges. Recent mass spectrometry advances are simplifying glycomic analysis for more precise results.

Keywords:

Glycomics Mass spectrometry-based analysis Technological advances

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A Quantitative Glycomics and Proteomics Combined Purification Strategy

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Published on: March 8, 2016

Area of Science:

Glycomics
Glycobiology
Mass Spectrometry

Background:

Glycomics seeks to define the complete glycome of biological systems.
Glycan complexity and diversity pose significant challenges to glycome definition.
Technological advancements are crucial for progress in glycomics.

Purpose of the Study:

To review current methods in glycomics.
To highlight recent advances in mass spectrometry-based glycomic analysis.
To outline the general workflow of glycomic analysis.

Main Methods:

Mass spectrometry-based techniques are central to modern glycomics.
The review follows the typical workflow of glycomic analysis.
Focus on recent technological innovations in mass spectrometry.

Main Results:

Recent mass spectrometry advances have reduced barriers in glycomics.
Glycomic analysis is becoming more accessible and efficient.
The field is progressing towards both broad and highly accurate glycan profiling.

Conclusions:

Technological progress, particularly in mass spectrometry, is transforming glycomics.
Glycomics is moving towards more precise and comprehensive glycan analysis.
These advances facilitate a better understanding of biological attributes of glycans.