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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
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Early Lymph Node Metastasis May Predict Poor Prognosis in Soft Tissue Sarcoma
Makoto Emori1, Hiroyuki Tsuchie2, Hiroyuki Nagasawa2
1Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
International Journal of Surgical Oncology
|January 10, 2020
Summary
Early lymph node metastasis (LNM) in soft tissue sarcoma is linked to a poorer prognosis. Detecting LNM within 8 months significantly reduces 5-year survival rates compared to later detection.
Area of Science:
- Oncology
- Pathology
Background:
- Lymph node metastasis (LNM) is uncommon in soft tissue sarcoma.
- The prognostic impact of LNM timing in soft tissue sarcoma remains unclear.
Purpose of the Study:
- To investigate the association between the timing of lymph node metastasis detection and patient prognosis in soft tissue sarcoma.
Main Methods:
- Retrospective analysis of 33 soft tissue sarcoma patients with LNM diagnosed between 2001 and 2015.
- Patients were categorized based on LNM detection within <8 months or ≥8 months from primary tumor diagnosis.
Main Results:
- No significant correlation was found between primary tumor size and LNM timing (p=0.96).
- Patients with LNM detected <8 months had a 5-year survival of 19%, versus 71% for those detected ≥8 months (p=0.0016).
- Early LNM (<8 months) was also associated with a higher incidence of pulmonary metastases (p=0.01).
Conclusions:
- Early detection of lymph node metastasis (<8 months) may indicate a poor prognosis in soft tissue sarcoma patients.
