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Updated: Aug 2, 2026
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
Early Lymph Node Metastasis May Predict Poor Prognosis in Soft Tissue Sarcoma
Makoto Emori1, Hiroyuki Tsuchie2, Hiroyuki Nagasawa2
1Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
Background:
Lymph node metastasis (LNM) is a relatively rare event in soft tissue sarcoma. An association between the timing of LNM detection and patient prognosis is presently unknown.
Patients And Methods:
We retrospectively analyzed the clinicopathological features of 33 patients with LNM between 2001 and 2015. Analysis of the timing of LNM diagnosis was grouped according to patients presenting LNM in either <8 months (the median time from primary tumor diagnosis to LNM) or ≥8 months after primary tumor diagnosis.
Results:
A relationship between the primary tumor size and the timing of the LNM was not significantly found (Rs = 0.0088, p=0.96). Sixteen patients had an LNM detection duration of <8 months, and 17 patients had a duration of ≥8 months. The 5-year survival for patients with an LNM detection duration of <8 months and ≥8 months was 19% and 71%, respectively (p=0.0016). There were 19 patients with pulmonary metastases. Among them, there were 13 patients with a duration of primary tumor diagnosis to LNM of <8 months and 6 with a duration of ≥8 months (p=0.01).
Conclusion:
Early LNM (<8 months) may predict poor prognosis in soft tissue sarcoma.
