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Updated: Dec 31, 2025
Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons
Published on: August 6, 2014
A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission
Zhe Chen1, Jingxiong Lu2, Fan Xiao3
1Cancer Centre and Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau, China. xuanjunzhang@um.edu.mo and Department of Materials Science and Engineering, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, China. tianll@sustech.edu.cn.
Abstract:
A new DNA nanoprobe based on a Y-shape and pyrene-modified DNA self-assembly is developed to sensitively and specifically detect microRNA through a pyrene excimer-monomer switch. Exhibiting the capability of self-delivery and resistance to nuclease degradation, the nanoprobe has been successfully applied for microRNA imaging in live cells.
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