Related Experiment Video
Updated: Dec 31, 2025

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
Published on: May 23, 2025
Classification and characteristics of periorbital hyperpigmentation
Amira M Fatin1, Thavin K Mathana Sundram1, Sin Sing E Tan1
1School of Healthy Aging, Medical Aesthetics and Regenerative Medicine, Faculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur, Malaysia.
Vascular perioral hyperpigmentation (POH) is common, often affecting both eyelids. While most individuals report no quality of life impact, a holistic approach is crucial for those affected.
Area of Science:
- Dermatology
- Aesthetics
- Ophthalmology
Background:
- Perioral hyperpigmentation (POH) is a frequent dermatological concern with limited data on prevalence and impact.
- Lack of standardized classification hinders understanding of POH's effect on well-being.
- Malaysia's diverse population offers a unique setting to study POH demographics.
Purpose of the Study:
- To develop a novel, clinically applicable classification system for perioral hyperpigmentation (POH).
- To assess the impact of POH on patients' quality of life.
Main Methods:
- Clinical assessment of 100 patients with POH.
- Objective measurements using a mexameter and digital analysis.
- Quality of life assessment via the Dermatology Life Quality Index (DLQI) questionnaire.
Main Results:
- Vascular POH was the most prevalent type (51%), while pigmentary POH was least common (6%).
- POH commonly affected both upper and lower eyelids (65%).
- The majority of patients (58%) reported no significant disruption to their quality of life.
Conclusions:
- Vascular POH is the predominant type, frequently involving both eyelids.
- While most patients are unaffected, the impact on quality of life for some necessitates consideration.
- A comprehensive, holistic management strategy is essential for POH, acknowledging its potential effect on patient well-being.
More Related Videos
Related Concept Videos
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Photoreceptors and Visual Pathways
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Accessory Structures of the Eye

