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Updated: Dec 31, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
The emerging role of cellular senescence in renal diseases
Bingru Zhou1, Ying Wan1, Rong Chen1
1Department of Pathophysiology, Southwest Medical University, Luzhou, China.
Abstract:
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence prevention, but it is also involved in many cardiovascular, renal and liver diseases through the senescence-associated secretory phenotype (SASP). This review summarizes the molecular mechanisms underlying cellular senescence and its possible effects on a variety of renal diseases. We will also discuss the therapeutic approaches based on the regulation of senescent and SASP blockade, which is considered as a promising strategy for the management of renal diseases.
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