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Composition of Blood Plasma

Composition of Blood Plasma

Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins,...

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Updated: Dec 31, 2025

Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation

Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation

Published on: May 17, 2021

Magnetically Levitated Plasma Proteins.

Ali Akbar Ashkarran¹, Kenneth S Suslick², Morteza Mahmoudi¹

¹Precision Health Program , Michigan State University , East Lansing , Michigan 48824 , United States.

Analytical Chemistry

|January 10, 2020

Summary

This summary is machine-generated.

Accurate protein density measurement is crucial for understanding biophysical properties. A new magnetic levitation (MagLev) technique using superparamagnetic iron oxide nanoparticles (SPIONs) precisely measured human plasma protein density in solution.

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Last Updated: Dec 31, 2025

Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation

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Published on: May 17, 2021

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Published on: August 7, 2014

Area of Science:

Biophysics
Biochemistry
Nanotechnology

Background:

Accurate measurement of protein densities in solution is a fundamental biophysical challenge.
Existing data limitations hinder the interpretation of protein physical and chemical characteristics.
Precise density values are essential for understanding protein behavior and interactions.

Purpose of the Study:

To introduce and validate a novel magnetic levitation (MagLev) technique for accurate protein density measurement in solution.
To address the lack of precise biophysical data for proteins.
To explore the potential of MagLev in protein science.

Main Methods:

Utilized superparamagnetic iron oxide nanoparticles (SPIONs) to enable magnetic levitation (MagLev).
Calibrated the MagLev system using standard density glass beads.
Levitated and measured the density of human plasma proteins in solution.

Main Results:

The MagLev technique successfully levitated human plasma proteins.
Measured protein density in solution was determined to be 1.03 ± 0.02 g/cm³.
This value is significantly lower than previously reported densities (∼1.35 g/cm³).

Conclusions:

Magnetic levitation (MagLev) offers a precise method for determining protein solution densities.
The novel findings challenge existing assumptions about protein densities.
This technique can enhance understanding of protein solution properties and interactions.