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Objective measurement of surfactant irritation by fiber optic spectroscopy
D M Crowe1, M S Willard, R I Murahata
1Department of New Science and Technology, Dial Technical Center, Scottsdale, AZ 85254.
Contact Dermatitis
|September 1, 1988
Abstract:
Erythema caused by occlusion of 3 concentrations of surfactant was quantified in vivo using a modified spectrophotometer. Standard chamber irritation test sites were evaluated objectively using the spectrophotometer and subjectively by trained observers. There was a good relationship between the instrumental and visual evaluations. The spectrum was analyzed and a region was chosen to optimize the sensitivity of the method.