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Methods for loading therapeutics into extracellular vesicles and generating extracellular vesicles
Amirmohammad Nasiri Kenari1, Lesley Cheng1, Andrew F Hill1
1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Australia.
Methods (San Diego, Calif.)
|January 10, 2020
Summary
Extracellular vesicles (EVs) show therapeutic promise but face challenges in yield and engineering. Biomimetic nanovesicles offer an alternative, customizable therapeutic approach.
Area of Science:
- Biotechnology
- Nanomedicine
- Cell Biology
Background:
- Extracellular vesicles (EVs) are cell-derived nanoparticles with theranostic potential.
- EVs facilitate intercellular communication by transferring biomolecules.
- Clinical translation of EVs is hindered by challenges in production and modification.
Purpose of the Study:
- To review current methods for modifying EVs.
- To discuss the generation and customization of EV mimetic-nanovesicles (M-NVs).
- To highlight M-NVs as a promising alternative therapeutic modality.
Main Methods:
- Review of existing literature on EV modification techniques.
- Analysis of methodologies for generating artificial EVs (M-NVs).
- Comparison of M-NVs characteristics with native EVs.
Main Results:
- EVs are promising for clinical applications but face challenges.
- Biomimetic EVs (M-NVs) can be engineered from various cell types.
- M-NVs offer comparable characteristics to EVs with enhanced customization.
Conclusions:
- EVs hold significant therapeutic potential, but challenges remain.
- M-NVs present a viable alternative for therapeutic applications.
- Further research into M-NVs generation and customization is warranted.
