Ciliary beat frequency in children with adenoid hypertrophy

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Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency
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Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency

Published on: November 10, 2021

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Lucia Marusiakova1, Peter Durdik1, Milos Jesenak1

  • 1Department of Paediatrics, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovakia.

Pediatric Pulmonology
|January 10, 2020
PubMed

Insights

Adenoid hypertrophy impairs children's airway defense by reducing ciliary beat frequency (CBF). Adenoidectomy restores normal CBF and alleviates rhinosinusitis symptoms, improving respiratory health.

Area of Science:

  • Otorhinolaryngology
  • Pediatric Respiratory Medicine
  • Cellular Physiology

Background:

  • Adenoid hypertrophy (AH) in children compromises respiratory defense mechanisms, notably mucociliary clearance.
  • This study investigates the impact of AH on ciliary beat frequency (CBF), a key component of mucociliary clearance, and the potential restorative effects of adenoidectomy.

Purpose of the Study:

  • To evaluate the influence of adenoid hypertrophy on nasal respiratory epithelium ciliary beat frequency (CBF) in children.
  • To assess the effect of endoscopic adenoidectomy on restoring CBF and improving clinical symptoms.

Main Methods:

  • A prospective study involving 64 children with AH and 43 healthy controls, aged 3-18 years.
  • Nasal CBF measurement using high-speed video microscopy and specialized software.
  • Assessment of adenoid size and rhinosinusitis symptoms via the SNOT-20 questionnaire.

Main Results:

  • Children with AH exhibited significantly lower median CBF (5.35 Hz) compared to controls (6.37 Hz).
  • Six months post-adenoidectomy, CBF significantly increased (6.48 Hz), normalizing to levels observed in healthy children.
  • Adenoidectomy also led to a significant reduction in rhinosinusitis symptom scores (SNOT-20).

Conclusions:

  • Clinically symptomatic adenoid hypertrophy is associated with impaired mucociliary clearance due to reduced nasal CBF.
  • Endoscopic adenoidectomy effectively normalizes CBF and alleviates associated rhinosinusitis symptoms in children.
Abstract

Keywords:
adenoid hypertrophyciliaciliary beat frequencydigital high-speed video microscopymucociliary clearance

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