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Acute right heart failure: future perspective with the PERKAT RV pulsatile right ventricular support device
Markus W Ferrari1, P Christian Schulze2, Daniel Kretzschmar2
1Director of the Clinic Internal Medicine 1, Helios Dr. Horst Schmidt Clinic, Ludwig-Erhard-Strasse 100, Wiesbaden, Hessen, 65199, Germany.
Therapeutic Advances in Cardiovascular Disease
|January 11, 2020
Summary
A new minimally invasive device, the PERKAT RV, offers rapid circulatory support for acute right heart failure. This innovative therapy effectively increased cardiac output by 59% in an animal model, addressing a critical unmet need.
Area of Science:
- Cardiology
- Medical Devices
- Hemodynamics
Background:
- Acute right heart failure significantly worsens prognosis in cardiogenic shock.
- Limited pharmacological options exist for right ventricular failure, necessitating novel circulatory support.
- The PERKAT RV is a novel, minimally invasive device designed for acute right heart support.
Discussion:
- The PERKAT RV functions by pumping blood from the inferior vena cava to the pulmonary artery, reducing central venous pressure.
- It operates with flow rates up to 4 liters/min, providing substantial circulatory assistance.
- The device's efficacy was demonstrated in an animal model following rigorous in vitro testing.
Key Insights:
- PERKAT RV demonstrated a 59% increase in cardiac output in sheep with acute right heart failure.
- This represents a significant advancement in managing acute right ventricular dysfunction.
- The study highlights the potential of mechanical circulatory support for right heart failure.
Outlook:
- First human implantation of the PERKAT RV is anticipated shortly.
- Future developments based on the PERKAT concept may extend to left heart support.
- This technology holds promise for improving outcomes in patients with severe heart failure.
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