Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serologic HLA typing in infantile spasms.

R A Hrachovy1, J D Frost, M S Pollack

  • 1Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.

Epilepsia
|November 1, 1988
PubMed
Summary

Human Leukocyte Antigen (HLA) typing revealed a significant increase in DRw52 frequency in infantile spasms patients, suggesting a potential role for immune system involvement in this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1.

Bone marrow transplantation·2014
Same author

Clinical severity and quality of life in children and adolescents with Rett syndrome.

Neurology·2011
Same author

Epilepsy and the natural history of Rett syndrome.

Neurology·2010
Same author

Specific mutations in methyl-CpG-binding protein 2 confer different severity in Rett syndrome.

Neurology·2008
Same author

Quantifying and visualizing uncertainty in EEG data of neonatal seizures.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
Same author

Quantifying motion in video recordings of neonatal seizures by feature trackers based on predictive block matching.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007

Area of Science:

  • Immunogenetics
  • Neurology
  • Pediatrics

Background:

  • Infantile spasms (IS) are a severe epilepsy syndrome in infants.
  • The exact pathophysiology of IS remains incompletely understood.
  • Genetic and immunological factors are suspected contributors.

Purpose of the Study:

  • To investigate the association between Human Leukocyte Antigen (HLA) antigen frequencies and infantile spasms.
  • To explore potential immunological mechanisms underlying IS development.

Main Methods:

  • Serologic HLA typing was conducted on 29 patients diagnosed with infantile spasms and hypsarrhythmic electroencephalograms (EEGs).
  • HLA-A, B, C, and DRw52 antigen frequencies were compared between the IS patient group and a control group.
  • Specific haplotype analysis (B18,DR3) was performed in a subset of white patients and controls.

Main Results:

  • No significant differences were observed in the frequencies of HLA-A, B, and C antigens between infantile spasm patients and controls.
  • A statistically significant increase in the frequency of the DRw52 antigen was found in infantile spasm patients (90%) compared to controls (72%).
  • The B18,DR3 (DRw52) haplotype was identified in 3 of 12 white infantile spasm patients, but in none of the 150 white control subjects.

Conclusions:

  • The findings suggest a potential association between the DRw52 antigen and infantile spasms.
  • The increased prevalence of the DRw52 antigen and the B18,DR3 haplotype supports the hypothesis that immunological mechanisms may play a role in the pathophysiology of infantile spasms.
  • Further research into immune system involvement in infantile spasms is warranted.

Related Experiment Videos