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[Research progress in NADPH oxidase family in cardiovascular diseases]

Jing Cao1, Zhaoya Liu1, Qian Xu1

  • 1Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|January 11, 2020
PubMed

Insights

Nicotinamide adenine dinucleotide phosphate oxidase (NOX) enzymes generate reactive oxygen species (ROS) in the cardiovascular system. These ROS play a key role in various cardiovascular diseases, highlighting NOX

Area of Science:

  • Cardiovascular Biology
  • Oxidative Stress Research
  • Molecular Medicine

Background:

  • Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a primary source of reactive oxygen species (ROS) in cardiovascular tissues.
  • The NOX enzyme family comprises seven isoforms, each with distinct cellular localization and functional roles within the cardiovascular system.

Purpose of the Study:

  • To elucidate the multifaceted roles of NOX-derived ROS in cardiovascular physiology and pathology.
  • To highlight the involvement of NOX isoforms in various cardiovascular diseases.

Main Methods:

  • Review of existing literature on NOX isoforms and their functions.
  • Analysis of the contribution of NOX-generated ROS to cellular processes like proliferation, migration, and apoptosis.
  • Examination of NOX involvement in the pathogenesis of cardiovascular diseases.

Main Results:

  • NOX enzymes modulate critical cellular functions including proliferation, migration, differentiation, apoptosis, and inflammatory responses.
  • NOX-derived ROS are implicated in the development and progression of hypertension, atherosclerosis, and diabetic vascular disease.
  • NOX activity contributes to ventricular remodeling following myocardial infarction.

Conclusions:

  • NOX enzymes are central regulators of cardiovascular health and disease through ROS production.
  • Targeting NOX isoforms represents a potential therapeutic strategy for managing a spectrum of cardiovascular conditions.

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