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Related Experiment Video

Updated: Dec 31, 2025

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
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Nanoscale plasmonic phase sensor.

Frank Wackenhut1, Lukas A Jakob2, Otto Hauler2

  • 1Institute of Physical and Theoretical Chemistry, Eberhard Karls University, Auf der Morgenstelle 18, 72076, Tuebingen, Germany. frank.wackenhut@uni-tuebingen.de.

Analytical and Bioanalytical Chemistry
|January 11, 2020
PubMed
Summary

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This summary is machine-generated.

Researchers developed a novel phase-based detection method for localized surface plasmon resonance (LSPR) sensing using single gold nanoparticles. This technique offers enhanced sensitivity for detecting molecular binding and refractive index changes.

Area of Science:

  • Nanotechnology and Nanoscience
  • Optical Sensing and Spectroscopy

Background:

  • Localized surface plasmon resonance (LSPR) of gold nanoparticles is a highly sensitive and selective sensing modality.
  • Existing LSPR sensing methods primarily rely on shifts in resonance wavelength or Fano resonance.

Purpose of the Study:

  • To introduce a new experimental approach for LSPR sensing utilizing the phase of scattered light from single gold nanoparticles.
  • To demonstrate a sensitive detection method for changes in local refractive index and molecular binding events.

Main Methods:

  • Equipped a confocal microscope with an interferometer arm (similar to a Michelson interferometer) to detect scattered light phase.
  • Analyzed the phase shift dependence on nanoparticle shape and surrounding medium's refractive index.
  • Explored detection capabilities even with off-resonant excitation of the gold nanoparticles.
Keywords:
Elastic scatteringGold nanotriangleOptical microscopyParticle plasmonPhaseSingle particle sensing

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Main Results:

  • Successfully detected the phase of light scattered by individual gold nanoparticles.
  • Demonstrated that the phase signal is sensitive to nanoparticle morphology and the local refractive index.
  • Showcased the potential for detecting molecular binding events through phase changes.

Conclusions:

  • The phase-based detection method offers a novel and sensitive alternative for LSPR sensing.
  • This approach expands the toolkit for single-nanoparticle sensing, enabling detection of subtle environmental changes.
  • The technique holds promise for various applications requiring high-sensitivity molecular detection and refractive index monitoring.