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Changes in liver function after different types of surgery.

R S Clarke, J R Doggart, T Lavery

    British Journal of Anaesthesia
    |February 1, 1976
    PubMed
    Summary
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    Minor surgery under anesthesia may cause transient liver function abnormalities, particularly after intra-abdominal procedures. Serum bilirubin and pseudocholinesterase levels were most affected, indicating potential liver stress during surgery.

    Area of Science:

    • Anesthesiology
    • Hepatology
    • Surgical Science

    Background:

    • Anesthesia and surgical procedures can impact physiological functions.
    • Assessing liver function post-surgery is crucial for patient recovery.
    • Previous studies have not comprehensively evaluated liver function changes after minor surgeries with varying invasiveness.

    Purpose of the Study:

    • To investigate the impact of minor surgical procedures under anesthesia on liver function.
    • To compare liver function test results across different surgical sites (body surface vs. intra-abdominal).
    • To identify specific liver function parameters affected by surgical stress.

    Main Methods:

    • Liver function tests (LFTs) were performed post-operatively.
    • Patients underwent minor surgical procedures under a 1-hour anesthesia duration.

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  • Surgical procedures were categorized into body surface and intra-abdominal operations.
  • Serum bilirubin, pseudocholinesterase, and intracellular enzyme levels (LDH, SGOT, SGPT) were measured.

    • Main Results:

    • No liver function abnormalities were observed after minor procedures with 1-hour anesthesia.
    • Transient liver function derangements were noted after body surface operations.
    • Intra-abdominal procedures resulted in more pronounced liver dysfunction.
    • Serum bilirubin showed the most frequent abnormalities; pseudocholinesterase decreased progressively; BSP retention increased significantly after intra-abdominal surgery.

    Conclusions:

    • Minor surgical procedures, especially intra-abdominal ones, can induce transient liver dysfunction.
    • Changes in bilirubin and pseudocholinesterase levels are key indicators of liver stress post-surgery.
    • Further research is needed to understand the long-term implications and mechanisms of these transient changes.