Related Experiment Video
Updated: Dec 31, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Outcomes Assessment of Multi-Level Sleep Surgery in Syndromic Versus Non-Syndromic Children
Suqrat Munawar1, Alexander P Marston1, Terral Patel1
1Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
Insights
Syndromic children undergoing sleep surgery have longer hospital stays, higher costs, and more complex outcomes than non-syndromic children. This difference is more pronounced with multi-level surgeries, highlighting the need for careful risk assessment.
Area of Science:
- Pediatric Otolaryngology
- Sleep Medicine
- Health Services Research
Background:
- Sleep disordered breathing and obstructive sleep apnea are common in children.
- Multi-level sleep surgery is an option for pediatric patients.
- Understanding outcomes in syndromic versus non-syndromic children is crucial.
Purpose of the Study:
- To compare length of stay, cost, disposition, and demographics between syndromic and non-syndromic children undergoing multi-level sleep surgery.
- To identify specific surgical factors influencing outcomes in these groups.
- To inform clinical decision-making for pediatric sleep surgery.
Main Methods:
- Retrospective analysis of the Kids' Inpatient Database (1997-2012).
- Classification of children into syndromic and non-syndromic groups.
- Stratification by surgical level: tonsillectomy & adenoidectomy (T&A), T&A plus other site, other site surgery.
- Statistical analysis using Kruskal-Wallis, logistic regression, and chi-square tests.
Main Results:
- Syndromic children were more likely to undergo multi-level surgery, had longer lengths of stay, higher costs, and non-routine dispositions (P < .001).
- Syndromic children undergoing T&A plus other site surgery had significantly longer stays than those with T&A alone (6.00 vs 3.63 days, P < .001).
- Non-syndromic children showed no significant difference in length of stay between these surgical groups (2.01 vs 2.87 days, P > .05).
Conclusions:
- Syndromic children face higher risks and resource utilization following sleep surgery compared to non-syndromic peers.
- The benefits and risks of sleep surgery, particularly multi-level procedures, require careful consideration in syndromic populations.
- Outcomes differ significantly based on syndromic status and surgical complexity, impacting length of stay and disposition.
Objectives:
Analyze the differences in length of stay, cost, disposition, and demographics between syndromic and non-syndromic children undergoing multi-level sleep surgery.
Methods:
Children with sleep disordered breathing or obstructive sleep apnea that had undergone sleep surgeries were isolated from the 1997 to 2012 editions of the Kids' Inpatient Database, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality. Children were then classified as syndromic or non-syndromic and stratified by level of sleep surgery (tonsillectomy & adenoidectomy, tonsillectomy & adenoidectomy plus other site surgery, other site surgery). Length of stay and cost were reported with Kruskal-Wallis one-way analysis of variance, disposition with binomial logistic regression, and demographics with chi-square.
Results:
Syndromic children compared to non-syndromic children were more likely to have surgery beyond just tonsillectomy & adenoidectomy and also had a longer length of stay, higher total cost and non-routine disposition (all P < .001). Syndromic children undergoing tonsillectomy and adenoidectomy plus other site surgery had a longer length of stay compared to syndromic children undergoing tonsillectomy & adenoidectomy (6.00 days vs 3.63 days, P < .001). However, no similar statistically significant difference in length of stay was found in non-syndromic children (2.01 days vs 2.87 days, P > .05).
Conclusion:
The potential risks/benefits need to be weighed carefully before undertaking sleep surgery in syndromic children. They experience a longer length of stay, higher cost, and non-routine disposition when compared to non-syndromic children. This is especially true when considering the transition from tonsillectomy & adenoidectomy to tonsillectomy & adenoidectomy plus other site surgery, as syndromic children experience a longer length of stay and non-syndromic children do not.
Related Concept Videos
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Narcolepsy
REM Sleep Behavior Disorder
RBD is significantly associated with...
Management of Insomnia

