Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.8K
Autoimmune Disorders01:29

Autoimmune Disorders

1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.2K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.2K
Development of Immunocompetence01:22

Development of Immunocompetence

702
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
702
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

2.8K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.8K
Humoral Immune Responses01:36

Humoral Immune Responses

83.1K
Overview
83.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coexistent alterations of BAFF and B-cell phenotypes in complicated CVID course.

The Journal of allergy and clinical immunology·2026
Same author

2025 Inborn errors of immunity practice parameter: Guidance from the Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI) and the Clinical Immunology Society (CIS).

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency.

JCI insight·2026
Same author

Diagnostic disparities in inborn errors of immunity: From clinical suspicion to diagnosis.

The journal of allergy and clinical immunology. Global·2025
Same author

Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses.

Science advances·2025
Same author

Curation of gene-disease relationships in primary antibody deficiencies using the ClinGen validation framework.

The Journal of allergy and clinical immunology·2025
Same journal

Mechanistic constraints in dengue severity: a systematic review with evidence stratification and agent-based evaluation of logical sufficiency.

Frontiers in immunology·2026
Same journal

Circadian control of immune homeostasis in cardiovascular health and disease.

Frontiers in immunology·2026
Same journal

An IHC-derived TLS-CD8-macrophage immune niche score predicts major pathological response to neoadjuvant chemoimmunotherapy in resectable NSCLC.

Frontiers in immunology·2026
Same journal

AF6 orchestrates macrophage polarization via JAK2-STAT3 signaling and supports intestinal regeneration by stimulating stem cell proliferation.

Frontiers in immunology·2026
Same journal

Restoring immune homeostasis in the spinal microenvironment: targeting mechano-inflammation and immunometabolic reprogramming.

Frontiers in immunology·2026
Same journal

A self-perpetuating neuron-intrinsic GSDMD-mtDNA-AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury.

Frontiers in immunology·2026
See all related articles

Related Experiment Video

Updated: Dec 31, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.7K

Current Understanding and Recent Developments in Common Variable Immunodeficiency Associated Autoimmunity.

Jessica D Gereige1, Paul J Maglione1

  • 1Department of Pulmonary, Allergy, Sleep & Critical Care Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, United States.

Frontiers in Immunology
|January 11, 2020
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) involves antibody deficiency and frequent infections. Autoimmune complications in CVID patients are linked to immune dysregulation, with ongoing research exploring genetic and microbial factors for better treatments.

Keywords:
autoimmunitycommon variable immunodeficiencycytopeniageneticsmicrobiomeprecision therapyprimary immunodeficieny

More Related Videos

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.4K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.2K

Related Experiment Videos

Last Updated: Dec 31, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.7K
Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.4K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.2K

Area of Science:

  • Immunology
  • Genetics
  • Autoimmunity

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by antibody deficiency and increased infection susceptibility.
  • Approximately half of CVID patients experience non-infectious complications, including autoimmune diseases, despite immune deficiency.

Purpose of the Study:

  • To explore the immune dysregulation underlying autoimmunity in CVID.
  • To understand the role of genetic factors and microbial dysbiosis in CVID pathogenesis and clinical heterogeneity.

Main Methods:

  • Analysis of immune cell populations, including T helper cells, B cells (CD21 expression), and regulatory T cells.
  • Leveraging advances in genomics to identify genetic etiologies of CVID-associated autoimmunity.

Main Results:

  • Identified immune dysregulation patterns in CVID, such as elevated T helper type 1 and follicular helper T cells, low CD21 B cells, and decreased regulatory T cells.
  • Genomic studies have begun to unravel the biological basis of autoimmunity in CVID, guiding precision therapies.

Conclusions:

  • Autoimmunity in CVID is associated with specific immune cell imbalances and genetic factors.
  • While progress has been made, further research is needed to fully elucidate CVID pathogenesis, optimize treatments, and understand the role of factors like microbial dysbiosis.