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Related Experiment Video

Updated: Dec 31, 2025

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

The Cellular Transcriptome in the Maternal Circulation During Normal Pregnancy: A Longitudinal Study.

Nardhy Gomez-Lopez^1,2,3, Roberto Romero^1,4,5,6,7,8, Sonia S Hassan^2,9

¹Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD and Detroit, MI, United States.

Frontiers in Immunology

|January 11, 2020

Summary

Maternal circulation immune gene expression changes significantly during pregnancy, with specific patterns observed in T cells, B cells, and erythroid cells, correlating with protein levels.

Keywords:

B cells T cells biomarker cytokines erythroid cells immunity pregnancy

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Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

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Last Updated: Dec 31, 2025

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

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Published on: December 5, 2015

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants

Published on: August 31, 2016

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

Area of Science:

Immunology
Genomics
Systems Biology

Background:

Pregnancy involves complex maternal immune adaptations to tolerate the semi-allogeneic fetus.
Cellular dynamics in maternal circulation during pregnancy are not well understood.

Purpose of the Study:

To analyze the dynamics of the cellular transcriptome in maternal circulation throughout normal pregnancy.
To correlate these transcriptional changes with the plasma proteome.

Main Methods:

Longitudinal exon-level expression profiling of whole blood samples from 49 pregnant women.
Systems biology analysis integrating transcriptome and proteome data.

Main Results:

Chromosome 14 showed enrichment in differentially expressed transcripts during pregnancy.
Immune response genes exhibited steady expression increases from 10 to 40 weeks of gestation.
Distinct longitudinal expression patterns were observed for T cells, B cells, and erythroid cells.
Higher correlation between mRNA and protein abundance was found for gestationally modulated genes, particularly in T-cell signatures.

Conclusions:

Longitudinal assessment reveals unique changes in maternal immune-related genes during pregnancy.
Positive correlations between cellular transcriptome and plasma proteome provide insights into pregnancy immunobiology.