Related Experiment Video
Updated: Dec 31, 2025
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
Published on: July 21, 2023
Selenium Level in Patients with Heart Failure versus Normal Individuals
Ahmad Mirdamadi1, Rahmatollah Rafiei2, Gharae Kahazaipour1
1Department of Cardiology, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran.
Insights
Patients with chronic heart failure (CHF) have lower serum selenium levels compared to healthy individuals. This deficiency is linked to increased risk factors and poorer cardiac function, highlighting selenium
Area of Science:
- Cardiology
- Nutritional Science
- Biochemistry
Background:
- Chronic heart failure (CHF) pathophysiology remains incompletely understood despite extensive research.
- Trace elements, particularly selenium, have been implicated in the development and progression of heart failure (HF).
- Selenium deficiency is a recognized risk factor for HF, prompting investigation into its role in patient populations.
Purpose of the Study:
- To compare serum selenium levels between patients diagnosed with heart failure (HF) and healthy control subjects.
- To investigate the relationship between selenium levels and clinical parameters in patients with HF.
Main Methods:
- A case-control study involving 32 hospitalized patients with HF and 32 healthy controls.
- Collection of demographic data, functional class, and risk factors for all participants.
- Echocardiography performed on HF patients; serum selenium levels measured and compared between groups.
Main Results:
- Serum selenium levels were significantly lower in HF patients (92.5 ± 22.44 mg/dL) compared to controls (109.3 ± 29.62 mg/dL).
- HF patients exhibited a higher frequency of risk factors compared to the control group.
- A significant inverse relationship was observed between selenium levels and left ventricular volume and pulmonary artery pressure in HF patients.
Conclusions:
- Patients with chronic heart failure (CHF) demonstrate statistically significant lower serum selenium levels than healthy individuals.
- Lower selenium levels in CHF patients correlate with increased left ventricular volume and pulmonary artery pressure.
Background:
Despite many attempts to discover pathophysiologic mechanisms to explain chronic heart failure (CHF), no conceptual paradigms have been proved yet. Various studies have shown the role of trace elements on heart failure (HF). Among all trace elements, selenium deficiency is regarded as important risk factors for HF. Considering selenium deficiency in our society and high prevalence of HF, we compared selenium level in patients with HF with healthy individuals.
Methods:
In all, 32 hospitalized patients with HF and 32 healthy controls were enrolled in a case-control study. Demographic characteristics as well as functional class and risk factors were recorded for all two groups. Echocardiography was conducted for patients and all provided data were registered. Then serum selenium levels were compared in case and control groups.
Results:
The mean (±standard deviation) serum selenium was 92.5 ± 22.44 mg/dL in patients with HF and 109.3 ± 29.62 mg/dL in controls. The level of selenium was significantly lower and the frequency of risk factors was significantly higher in case group. Selenium level did not differ significantly in patients with different HF causes. There were a nonsignificant relationship between selenium level and left ventricular ejection fraction and a significant reverse relationship between selenium level and left ventricular volume and pulmonary artery pressure.
Conclusions:
Our results showed statistically significant lower level of serum selenium in patients with CHF in comparison to normal individuals. Moreover, selenium level had significant reverse relationship with left ventricular volume and pulmonary artery pressure.
More Related Videos
04:20Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure
Published on: October 1, 2019
05:16Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Related Concept Videos
01:30Heart Failure VII: Nursing Interventions
01:22Heart Failure VI: Adjunct Therapies
01:29Heart Failure II: Pathophysiology
01:27Heart Failure I: Introduction
01:30Heart Failure IV: Classification and Diagnostic Evaluation
01:26Heart Failure III: Clinical Manifestations