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Updated overview on interplay between physical exercise, neurotrophins, and cognitive function in humans
Giuseppe Lippi1, Camilla Mattiuzzi2, Fabian Sanchis-Gomar3
1Section of Clinical Biochemistry, University of Verona, Verona 37129, Italy.
Journal of Sport and Health Science
|January 11, 2020
Summary
Regular physical exercise enhances cognitive functions by increasing brain-derived neurotrophic factor (BDNF). Moderate aerobic activity for 3 months may preserve or restore cognitive abilities safely and affordably.
Area of Science:
- Neuroscience
- Exercise Physiology
- Cognitive Health
Background:
- Physical exercise offers significant benefits for cognitive function maintenance and improvement.
- Neurotrophin receptor signaling is a key mechanism linking exercise to brain health, promoting neurogenesis and synaptic plasticity.
- Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal survival, growth, and differentiation.
Purpose of the Study:
- To review the evidence on the relationship between physical exercise and neurotrophins, particularly BDNF.
- To explore the association between exercise-induced changes in BDNF and cognitive function.
- To assess the potential of physical exercise as a strategy for cognitive enhancement.
Main Methods:
- Systematic review of published scientific literature.
- Analysis of studies investigating the effects of physical exercise on neurotrophin levels.
- Correlation analysis between physical activity parameters and neurocognitive outcomes.
Main Results:
- A positive correlation exists between physical exercise and circulating BDNF levels.
- Post-exercise increases in BDNF are linked to improvements in neurocognitive functioning.
- Evidence for other neurotrophins (NGF, NT-3, NT-4) is less conclusive.
Conclusions:
- Moderate-intensity aerobic exercise (e.g., 3 months, 2-3 sessions/week, ≥30 min) effectively boosts BDNF release.
- Physical exercise is a cost-effective and safe method for enhancing BDNF and supporting cognitive functions.
- Promoting regular exercise is a viable strategy for preserving and restoring cognitive health throughout life.
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