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Related Experiment Video

Updated: Dec 31, 2025

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth
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Next-Generation Liver Medicine Using Organoid Models.

Soheil Akbari1, Nur Arslan1,2, Serif Senturk1,3

  • 1İzmir Biomedicine and Genome Center, İzmir, Turkey.

Frontiers in Cell and Developmental Biology
|January 11, 2020
PubMed
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Clinical utility and genomic insights from whole exome and clinical exome sequencing in idiopathic liver disease.

Human molecular genetics·2026

Organoid technology offers advanced 3D models for studying liver diseases and developing patient-specific therapies. These liver organoids represent a significant leap in understanding liver pathophysiology and drug screening.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Hepatology

Background:

  • Liver medicine requires better tools to understand disease and develop treatments.
  • Organoid technology provides advanced 3D models that mimic organ structure and function.
  • Liver organoids can be generated from stem cells, recapitulating in vivo liver physiology.

Purpose of the Study:

  • To review recent advances in human liver organoid generation.
  • To highlight challenges in current organoid technology.
  • To explore potential applications of liver organoids in liver medicine.

Main Methods:

  • Utilizing pluripotent stem cells or liver-specific stem/progenitor cells.
  • Employing exogenous factors to regulate signaling pathways for organogenesis.
Keywords:
3D cell culture systemsadult stem cellsdisease modelingiPSCsliverorganoids

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  • Culturing organoids in 3D matrices to promote self-organization.

    • Main Results:

    • Established robust, long-term cultures of liver organoids closely resembling in vivo liver.
    • Demonstrated organoids' utility for disease pathology studies and high-throughput drug screening.
    • Highlighted potential for integrating genome editing and bioengineering for enhanced applications.

    Conclusions:

    • Human liver organoids represent a next-generation cell culture system for liver medicine.
    • Organoid technology holds immense potential for personalized therapeutics and clinical applications.
    • Further advancements in organoid technology promise to revolutionize liver disease research and treatment.