Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

1.2K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.2K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

168
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
168
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

152
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
152
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

2.9K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.9K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

202
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
202
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

1.4K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Consensus to Practice: Implementation and Impact of the Emergency Medicine Simulation Curriculum for Pediatrics (EM ReSCu Peds).

Cureus·2026
Same author

Idiopathic granulomatous mastitis as an autoimmune disease: A review of immunopathogenesis and therapeutic response.

Autoimmunity reviews·2026
Same author

Nuclear Proteome Map of Mouse Heart Chambers.

Molecular & cellular proteomics : MCP·2026
Same author

B7-H3 (CD276) as Target for T Cell-Based Bispecific Antibody Therapy of Penile Cancer.

ImmunoTargets and therapy·2026
Same author

Spatio-temporal targeting of cardiac cells with lipid nanoparticles after myocardial infarction.

Journal of molecular and cellular cardiology plus·2026
Same author

Hydrocelectomy under local anesthesia with systemic analgesic support: real-world feasibility and patient acceptance.

International urology and nephrology·2026

Related Experiment Video

Updated: Dec 31, 2025

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
04:36

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum

Published on: August 5, 2020

4.7K

Pediatric Toxidrome Simulation Curriculum: Bupropion Overdose.

Emily Hartford1,2, Anita Thomas1,2, Ashley Keilman1,2

  • 1Assistant Professor, Department of Pediatrics, Division of Emergency Medicine, University of Washington School of Medicine.

Mededportal : the Journal of Teaching and Learning Resources
|January 11, 2020
PubMed
Summary

This study presents a pediatric emergency department simulation for managing bupropion overdose, a critical scenario involving seizures and cardiac toxicity. The interprofessional team training enhanced participants' ability to manage this complex overdose case effectively.

Keywords:
Bupropion OverdoseEmergency MedicineMedical ToxicologySeizureSimulationToxidromeVentricular Tachycardia

More Related Videos

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.4K
Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
07:41

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

Published on: June 5, 2017

10.3K

Related Experiment Videos

Last Updated: Dec 31, 2025

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
04:36

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum

Published on: August 5, 2020

4.7K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.4K
Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
07:41

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

Published on: June 5, 2017

10.3K

Area of Science:

  • Emergency Medicine
  • Medical Simulation
  • Pediatric Toxicology

Background:

  • Bupropion overdose can cause severe neurologic and cardiovascular toxicity.
  • Prompt recognition and management are crucial in pediatric cases.

Purpose of the Study:

  • To develop and evaluate a simulation case for managing bupropion overdose in a pediatric emergency department.
  • To assess the impact of interprofessional team training on managing bupropion toxicity.

Main Methods:

  • A simulation scenario involving a 13-year-old male with bupropion overdose, altered mental status, seizure, and pulseless ventricular tachycardia was created.
  • The simulation included primary/secondary surveys, airway management, seizure treatment, and advanced cardiac life support.
  • Interprofessional teams (physicians, nurses, NPs, pharmacists, students, respiratory therapists) participated in 13 sessions.

Main Results:

  • Participants reported improved ability to manage bupropion overdose (M = 4.09).
  • The scenario was rated as highly relevant (M = 4.93) and the debriefing as very effective (M = 4.85).
  • Learners from diverse professional backgrounds worked together in actual care teams.

Conclusions:

  • The simulation serves as a comprehensive educational resource for interprofessional teams in pediatric emergency settings.
  • This training effectively prepared healthcare providers to manage bupropion overdose cases.
  • The simulation was well-received and highly rated by participants.