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Serum C-peptide and osteocalcin levels in children with recently diagnosed diabetes

Omaima M Sabek1,2, Maria J Redondo3, Duc T Nguyen4

  • 1Department of Surgery The Methodist Hospital Houston TX USA.

Endocrinology, Diabetes & Metabolism
|January 11, 2020
PubMed

Insights

In children with new-onset diabetes, C-peptide levels correlate with bone metabolism markers. Higher C-peptide and BMI in type 1 diabetes predict partial remission, indicating preserved beta-cell function.

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Pediatric Diabetes Research

Background:

  • Investigated C-peptide, proinsulin, and their ratio (PI/C) as markers of beta-cell stress.
  • Examined associations with undercarboxylated (uOC) and carboxylated osteocalcin (cOC) and their ratio (uOC/cOC).
  • Studied these markers in children with newly diagnosed type 1 (T1D) or type 2 diabetes (T2D).

Purpose of the Study:

  • To explore the association of beta-cell stress markers with bone metabolism markers in pediatric diabetes.
  • To correlate these variables with partial remission (PR) in children with T1D.

Main Methods:

  • Collected demographic and clinical data from 68 children with new-onset diabetes.
  • Measured serum proinsulin, C-peptide, uOC, and cOC levels approximately 7 weeks post-diagnosis.
  • Defined partial remission (PR) as insulin dose-adjusted HbA1c (IDAA1c) ≤9.

Main Results:

  • Found a positive association between C-peptide levels and both uOC and uOC/cOC ratio in children with T1D and T2D.
  • In T1D, higher C-peptide and lower PI:C ratio correlated with higher BMI percentile and older age at diagnosis.
  • C-peptide levels at visit 1 predicted partial remission (IDAA1c ≤9) in T1D children.

Conclusions:

  • C-peptide levels are linked to higher uOC and uOC/cOC ratios in pediatric diabetes.
  • In new-onset T1D, older age and higher BMI are associated with reduced beta-cell stress and preserved function.
  • These factors predict partial remission in children with type 1 diabetes.
Abstract

Keywords:
C‐peptidediabetesosteocalcinpaediatrics

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