Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variable predictors of acute pulmonary embolism recurrence with duration of follow-up.

Journal of thoracic disease·2020
Same author

Is the result of modified Allen's test still accurate after endoscopic thoracic sympathectomy?

Journal of thoracic disease·2020
Same author

[Extracellular histones are involved in lipopolysaccharide-induced alveolar macrophage injury by activating the TWIK2-NLRP3 pathway].

Zhonghua wei zhong bing ji jiu yi xue·2020
Same author

Application of a bilayer tubular scaffold based on electrospun poly(l-lactide-co-caprolactone)/collagen fibers and yarns for tracheal tissue engineering.

Journal of materials chemistry. B·2020
Same author

Isolation of two rare N-glycosides from Ginkgo biloba and their anti-inflammatory activities.

Scientific reports·2020
Same author

Serum Metabolic Profiling Reveals the Antidepressive Effects of the Total Iridoids of <i>Valeriana jatamansi</i> Jones on Chronic Unpredictable Mild Stress Mice.

Frontiers in pharmacology·2020

Related Experiment Video

Updated: Dec 31, 2025

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.1K

Shape characterization and discrimination of single nanoparticles using solid-state nanopores.

Wei Si1, Jingjie Sha, Qianyi Sun

  • 1School of Mechanical Engineering, Southeast University, Nanjing 211189, China. major212@seu.edu.cn yunfeichen@seu.edu.cn.

The Analyst
|January 11, 2020
PubMed
Summary

Solid-state nanopores can now determine the 3D shape of nanoparticles. This low-cost, high-throughput method analyzes ionic current blockades during particle translocation for advanced nanoscale object analysis.

More Related Videos

High Resolution Physical Characterization of Single Metallic Nanoparticles
09:56

High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

6.1K
Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

14.0K

Related Experiment Videos

Last Updated: Dec 31, 2025

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.1K
High Resolution Physical Characterization of Single Metallic Nanoparticles
09:56

High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

6.1K
Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

14.0K

Area of Science:

  • Nanotechnology
  • Biophysics
  • Materials Science

Background:

  • Resistive pulse sensing using nanopores offers potential for nanoscale object analysis in ionic solutions.
  • Current methods for characterizing the 3D shape of charged biomolecules or nanoparticles are limited in cost-effectiveness and throughput.

Purpose of the Study:

  • To demonstrate the capability of solid-state nanopores for characterizing the 3D shape of single nanoparticles.
  • To develop a low-cost, high-throughput method for nanoscale shape analysis.

Main Methods:

  • Monitoring ionic current blockades during the electrophoretic translocation of nanoparticles through solid-state nanopores.
  • Utilizing nanopores slightly larger than the nanoparticles to allow for rotation.
  • Validation through all-atom molecular dynamics simulations.

Main Results:

  • Successful shape characterization of both spherical and cubic silver nanoparticles.
  • Demonstrated that rapid rotation of nanoparticles within the nanopore is key to shape determination.
  • Validated experimental findings with molecular dynamics simulations.

Conclusions:

  • Solid-state nanopore sensing is a viable technique for real-time, single-molecule 3D shape characterization of nanoparticles.
  • This approach enables simultaneous measurement of dimension and shape for nanoparticles or proteins.
  • Potential applications include structural biology and proteomics research.