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Non-random chromosomal aberrations in a complex leukaemic clone of a Bloom's syndrome patient
F Shabtai1, U H Lewinski, A Meroz
1Gattegno Research Institute for Human Reproduction and Fetal Development, Hasharon Hospital, Golda Medical Center, Tel Aviv University Medical School, Petah-Tiqva, Israel.
Human Genetics
|November 1, 1988
Abstract:
Bloom's syndrome is one of the congenital disorders known to have increased frequency of acute leukaemia. The complex cytogenetic findings in the leukaemic cells of a 39-year-old male with Bloom's syndrome are described. These included a translocation t(7;17), missing 7q and 17p, a reciprocal translocation t(4;22); del 3q, del 8q22, del 20q, missing 12 and missing Y. In the same patient a missing Y had been noted 10 years previously in 15% of his peripheral blood lymphocytes.