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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Area of Science:

  • Immunology
  • Gastroenterology
  • Microbiology

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease with unknown causes.
  • Genetic and environmental factors are implicated in SSc pathogenesis.
  • The gastrointestinal tract (GIT) microbiota is increasingly recognized as a potential factor in SSc.

Purpose of the Study:

  • To review studies investigating the GIT microbiota in SSc patients.
  • To highlight modifications in GIT microbiota composition across different SSc cohorts.
  • To explore the association between GIT microbiota alterations and SSc features.

Main Methods:

  • Literature review of studies on SSc and GIT microbiota.
  • Comparative analysis of microbiota data from SSc patients.
  • Cross-disease comparison with other autoimmune conditions.

Main Results:

  • Specific alterations in GIT microbial composition are observed in SSc patients.
  • These changes may correlate with distinct SSc phenotypes.
  • Similarities and differences exist between SSc microbiota and that of other autoimmune diseases.

Conclusions:

  • The GIT microbiota plays a potential role in SSc pathogenesis.
  • Targeting the GIT microbiota may offer novel therapeutic strategies for SSc.
  • SSc therapies modulating GIT microbiota may require combination with other treatments.