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Related Experiment Videos

Which Drug Next? Sequential Therapy for Osteoporosis.

Barbara P Lukert1

  • 1Division of Endocrinology, Metabolism & Genetics, Department of Medicine, University of Kansas School of Medicine, Kansas City, Kansas.

The Journal of Clinical Endocrinology and Metabolism
|January 11, 2020
PubMed
Summary

New osteoporosis drugs offer benefits but require follow-up treatments. Alendronate effectively preserves bone gained during denosumab therapy, preventing rapid bone loss after treatment cessation.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Background:

  • Osteoporosis treatment has evolved with new drugs beyond bisphosphonates (BPs).
  • Concerns about long-term bisphosphonate complications have shifted prescribing practices.
  • Novel osteoporosis medications (e.g., denosumab, romosozumab) offer unique mechanisms but pose challenges like rapid bone loss post-treatment.

Purpose of the Study:

  • To evaluate the efficacy of alendronate in preserving bone mass after denosumab treatment.
  • To address the challenge of bone loss following withdrawal of bone-building osteoporosis therapies.

Main Methods:

  • The study investigated the effect of alendronate administration following denosumab therapy.
  • Bone mineral density changes were assessed in patients transitioning between these treatments.
Keywords:
anabolic agentsanti-resorptive agentsdenosumabosteoporosis

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Main Results:

  • Alendronate successfully preserved bone mass that was accrued during denosumab treatment.
  • This indicates that alendronate can mitigate the rapid bone resorption that occurs after denosumab withdrawal.

Conclusions:

  • Transitioning from denosumab to alendronate is an effective strategy to maintain bone gains.
  • This approach helps manage osteoporosis by preventing rebound bone loss and sustaining therapeutic benefits.