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Changes in resting-state functional connectivity in nonacute sciatica with acupuncture modulation: A preliminary

Ching-Hsiung Liu1,2,3, Tzu-Chen Yeh3,4,5, Yen-Ying Kung2,6,7

  • 1Department of Neurology, Lotung Poh-Ai Hospital, Ilan, Taiwan.

Brain and Behavior
|January 11, 2020
PubMed
Summary

Acupuncture treatment for sciatica patients normalized default mode network (DMN) activity, suggesting a mechanism for pain relief. This study explored functional connectivity (FC) changes in the brain after acupuncture.

Keywords:
acupuncturedefault mode networkfunctional connectivitymagnetic resonance imagingsciatica

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Pain Management

Background:

  • Sciatica is a condition characterized by pain radiating along the path of the sciatic nerve.
  • Understanding the neural mechanisms underlying sciatica and the effects of treatments like acupuncture is crucial for effective pain management.

Purpose of the Study:

  • To investigate functional connectivity (FC) in patients with nonacute sciatica.
  • To explore the neuronal correlation of acupuncture's pain-relieving effects in sciatica patients.

Main Methods:

  • A prospective study utilizing resting-state functional magnetic resonance imaging (fMRI).
  • Twelve sciatica patients received acupuncture treatment twice weekly for four weeks.
  • Analysis included regional homogeneity (ReHo) and seed-based FC, focusing on the posterior cingulate cortex (PCC) and default mode network (DMN).

Main Results:

  • Acupuncture altered regional homogeneity in the right PCC.
  • Sciatica patients showed altered PCC-seeded DMN connectivity (hyperconnectivity pre-acupuncture, hypoconnectivity post-acupuncture) compared to controls.
  • Pre-acupuncture FC in the right inferior parietal lobule positively correlated with sciatica duration.

Conclusions:

  • Acupuncture is associated with normalized DMN activity and modulated descending pain processing in chronic sciatica.
  • Observed changes in brain FC after acupuncture may elucidate the mechanism of acupuncture analgesia in chronic pain conditions.