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The Contractile Ring

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...

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Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

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Threaded Rings that Swim in Excitable Media.

Antonio Cincotti^1,2, Fabian Maucher^1,3,4, David Evans¹

¹Department of Mathematical Sciences, Durham University, Durham DH1 3LE, United Kingdom.

Physical Review Letters

|January 11, 2020

Summary

This summary is machine-generated.

A novel threaded ring (thring) in excitable media exhibits unique swimming motion. This study proposes and confirms a light templating method to create this complex scroll wave structure.

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Area of Science:

Complex systems
Nonlinear dynamics
Chemical kinetics

Background:

Excitable media, such as cardiac tissue and the Belousov-Zhabotinsky reaction, support scroll waves.
Scroll waves are characterized by a filament core generating spiral waves of excitation.

Purpose of the Study:

To investigate a novel topological configuration of scroll waves: a scroll ring threaded by counterrotating filaments.
To simulate and analyze the dynamics of this threaded ring (thring) in a photosensitive excitable medium.
To develop and experimentally validate a light templating protocol for creating thrings.

Main Methods:

Simulations using modified Oregonator reaction-diffusion equations for the photosensitive Belousov-Zhabotinsky medium.
Analysis of the dynamics of the threaded ring topology.
Development and experimental testing of a light templating protocol.

Main Results:

The threaded ring (thring) exhibits exotic swimming motion within the plane of the ring.
The proposed light templating protocol successfully creates the thring structure in experiments.
The threading topology is shown to be the cause of the observed swimming behavior.

Conclusions:

A novel threaded scroll ring (thring) configuration in excitable media displays unique self-swimming dynamics.
Light templating offers a viable method for the experimental creation of complex scroll wave topologies.
This research advances the understanding of topological effects on wave dynamics in excitable systems.