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Involvement of regulated necrosis in blinding diseases: Focus on necroptosis and ferroptosis

Jing-Jie Peng1, Wei-Tao Song2, Fei Yao2

  • 1Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, 410008, China; Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.

Experimental Eye Research
|January 11, 2020
PubMed

Insights

Regulated necrosis, a programmed cell death, contributes to blinding diseases like glaucoma. This review examines necroptosis and ferroptosis roles in retinal cell degeneration.

Area of Science:

  • Cellular Biology
  • Pathology
  • Ophthalmology

Background:

  • Regulated necrosis is a genetically controlled cell death pathway distinct from apoptosis, involving membrane integrity loss.
  • Classifications include necroptosis, ferroptosis, pyroptosis, and parthanatos, implicated in various organ diseases.
  • Emerging evidence links regulated necrosis to retinal cell degeneration in blinding conditions.

Purpose of the Study:

  • To review the involvement of necroptosis and ferroptosis in blinding diseases.
  • To highlight their contribution to retinal cell degeneration.

Main Methods:

  • Literature review focusing on necroptosis and ferroptosis.
  • Analysis of studies on glaucoma, age-related macular degeneration, and retinitis pigmentosa.

Main Results:

  • Necroptosis and ferroptosis are key contributors to retinal ganglion cell, retinal pigment epithelial, and photoreceptor cell loss.
  • These regulated necrosis pathways are central to the pathology of major blinding diseases.

Conclusions:

  • Necroptosis and ferroptosis are critical therapeutic targets for blinding diseases.
  • Understanding these pathways is crucial for developing novel treatments for vision loss.
Keywords:
Age-related macular degenerationFerroptosisGlaucomaNecroptosisRegulated necrosisRetinitis pigmentosa

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