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Natural polypeptides-based electrically conductive biomaterials for tissue engineering
Somayeh Vandghanooni1, Morteza Eskandani2
1Research Center for Pharmaceutical Nanotechnology, Biomedicine institute, Tabriz University of Medical Sciences, Tabriz, Iran; Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
International Journal of Biological Macromolecules
|January 11, 2020
Summary
Tissue engineering scaffolds are crucial for cell behavior. Combining natural polypeptides with electrically conductive polymers (ECPs) offers superior materials for advanced tissue regeneration applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Scaffold fabrication is fundamental for successful tissue engineering (TE).
- Artificial scaffolds mimic the extracellular matrix, influencing cell attachment, proliferation, differentiation, and movement.
- Chemical and electrical stimuli impact cell polarity and functionality, necessitating careful scaffold design.
Purpose of the Study:
- To review the simultaneous use of natural polypeptides and electrically conductive polymers (ECPs) for scaffold fabrication in TE.
- To highlight the potential of these composites for creating scaffolds with enhanced biological and physicochemical properties.
Main Methods:
- Literature review focusing on the combination of natural polypeptides and ECPs.
- Analysis of existing research on scaffold fabrication for TE.
Main Results:
- Natural polypeptides and ECPs can be combined to create composite scaffolds.
- These composites offer potential for superior biological and physicochemical features compared to scaffolds made from single materials.
Conclusions:
- The combination of natural polypeptides and ECPs presents a promising strategy for developing advanced TE scaffolds.
- Further research into these composite materials could lead to significant advancements in tissue regeneration.
