Related Experiment Video
Updated: Dec 31, 2025

Tricolor Transgenic Murine Model for Studying Growth Plate Injury
Published on: September 6, 2024
Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update
Silvana Duran-Ortiz1, Vanessa Noboa2, John J Kopchick3
1Edison Biotechnology Institute, United States of America; Department of Biological Sciences, College of Arts and Sciences, United States of America; Molecular and Cellular Biology Program, United States of America.
Abstract:
The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.
Related Concept Videos
Hedgehog Signaling Pathway
In-vitro Mutagenesis
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

