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Related Experiment Video

Updated: Dec 31, 2025

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Bioactive pterocarpans from Trigonella foenum-graecum L.

Zi Wu1, You-Sheng Cai1, Ruiying Yuan1

  • 1Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.

Food Chemistry
|January 11, 2020
PubMed
Summary
This summary is machine-generated.

Fenugreek

Keywords:
(-)-melilotocarpan D (PubChem CID: 5319351)4-methoxymedicarpin (PubChem CID: 14077265)Anti-inflammatoryAntioxidantPterocarpanTrigonella foenum-graecummaackiain (PubChem CID: 161298)medicarpin (PubChem CID: 73067)

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Food Science

Background:

  • Trigonella foenum-graecum L. (fenugreek) is a widely consumed plant in China and North Africa.
  • The biochemical composition and bioactivities of fenugreek's aerial parts remain underexplored.
  • Previous research has not focused on the pterocarpan constituents of fenugreek.

Purpose of the Study:

  • To investigate the bioactivities of extract fractions from fenugreek aerial parts.
  • To isolate and identify bioactive compounds, specifically pterocarpans.
  • To evaluate the antioxidant and anti-inflammatory potential of isolated compounds.

Main Methods:

  • Extraction and fractionation of fenugreek aerial parts.
  • Bioassay-guided isolation of pterocarpans using antioxidant and anti-inflammatory assays.
  • Chemical characterization of isolated compounds through spectroscopic methods.

Main Results:

  • The ethyl acetate fraction showed significant antioxidant and anti-inflammatory effects.
  • One novel and twelve known pterocarpans were isolated; nine were newly reported in fenugreek.
  • Pterocarpans 9, 11-13 exhibited strong antioxidant activity, while 1-3 and 5-12 demonstrated significant anti-inflammatory effects.

Conclusions:

  • Pterocarpans are identified as the primary bioactive constituents in the aerial parts of fenugreek.
  • Fenugreek's aerial parts possess potential as a source for functional foods and natural antioxidants.
  • Further exploration of fenugreek's pterocarpans could lead to novel applications in the food and pharmaceutical industries.